Myrtle Mae Urkel made her first appearance season 2, episode 8: Cousin Urkel (as an exchange agreement between Big Daddy Urkel and Dr.Urkel). Played by Jaleel White, Myrtle was a rich Southern belle from Biloxi, Mississippi (living in the fictional Urkel Oaks, a rich antibellum house presumably in Biloxi's rural outskirts) who fell in love with Eddie at first sight, despite his obvious dislike for her. Her rich father, Big Daddy Urkel (played by Reginald VelJohnson), was a loving and caring father to Myrtle but did not approve of Eddie being his daughter's boyfriend except when bribed with cash. Like Urkel did in his pursuit for Laura, she frequently went to great lengths to capture the object of her affection, such as sneaking into his bedroom at night and trying to kiss him. However, unlike Steve, Myrtle refused to ever leave Eddie alone and disrespects his personal space by stalking him, much to his extreme terror. After several years away, she returned to Chicago to visit her cousin and renew her pursuit of Eddie; by this time, he and Greta had started dating. Unlike Laura's would-be boyfriends, Greta was more successful in warding Myrtle off. Finally, in the episode Don't Make Me Over, she relinquished her love for Eddie and pursued other guys after finally realizing he does not like her. </span>
Had the show continued for a final tenth season, Myra and Myrtle would become friends and have a girls' night out, but get held hostage at one of the clubs. Eddie rescued the girls, but Myrtle still acted very cold around him. She also had a good time helping Stefan get to know the Urkel family before he disappeared in Death of Stefan. It is unknown on whether or not she would witness the birth of Stephanie Laurine Urkel or not, as this would have been her true final appearance in the series.